SrasV1, Main, Exploration, bibRecord, 001364

Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives.

Identifieur interne : 001364 ( Main/Exploration ); précédent : 001363; suivant : 001365

Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives.

Auteurs : Aidang Lu [République populaire de Chine] ; Ziwen Wang ; Zhenghong Zhou ; Jianxin Chen ; Qingmin Wang

Source :

Journal of agricultural and food chemistry [ 1520-5118 ] ; 2015.

RBID : pubmed:25619875

Descripteurs français

KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Conception de médicament, Liaison hydrogène, Maladies des plantes (virologie), Relation structure-activité, Tabac (virologie), Thiourée (), Virus de la mosaïque du tabac ().
MESH :
- pharmacologie : Antiviraux.
- synthèse chimique : Antiviraux.
- virologie : Maladies des plantes, Tabac.
- Antiviraux, Conception de médicament, Liaison hydrogène, Relation structure-activité, Thiourée, Virus de la mosaïque du tabac.

English descriptors

KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Drug Design, Hydrogen Bonding, Plant Diseases (virology), Structure-Activity Relationship, Thiourea (chemistry), Tobacco (virology), Tobacco Mosaic Virus (drug effects).
MESH :
- chemical , chemical synthesis : Antiviral Agents.
- chemical , chemistry : Antiviral Agents, Thiourea.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Tobacco Mosaic Virus.
- virology : Plant Diseases, Tobacco.
- Drug Design, Hydrogen Bonding, Structure-Activity Relationship.

Abstract

A series of simple thiourea derivatives were designed based on the structure of natural product harmine and lead compound and synthesized from amines in one step. The antiviral activity of these thiourea derivatives was evaluated. Most of them exhibited significantly higher anti-TMV activity than commercial plant virucides ribavirin, harmine, and lead compound. The hydrogen bond was found to be important but not the more the better. The optimal compound (R,R)-20 showed the best anti-TMV activity in vitro and in vivo (in vitro activity, 75%/500 μg/mL and 39%/100 μg/mL; inactivation activity, 71%/500 μg/mL and 35%/100 μg/mL; curative activity, 73%/500 μg/mL and 37%/100 μg/mL; protection activity, 69%/500 μg/mL and 33%/100 μg/mL), which is significantly higher than that of Ningnanmycin. The systematic study provides strong evidence that these simple thiourea derivatives could become potential TMV inhibitors.

DOI: 10.1021/jf505355r
PubMed: 25619875

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">A series of simple thiourea derivatives were designed based on the structure of natural product harmine and lead compound and synthesized from amines in one step. The antiviral activity of these thiourea derivatives was evaluated. Most of them exhibited significantly higher anti-TMV activity than commercial plant virucides ribavirin, harmine, and lead compound. The hydrogen bond was found to be important but not the more the better. The optimal compound (R,R)-20 showed the best anti-TMV activity in vitro and in vivo (in vitro activity, 75%/500 μg/mL and 39%/100 μg/mL; inactivation activity, 71%/500 μg/mL and 35%/100 μg/mL; curative activity, 73%/500 μg/mL and 37%/100 μg/mL; protection activity, 69%/500 μg/mL and 33%/100 μg/mL), which is significantly higher than that of Ningnanmycin. The systematic study provides strong evidence that these simple thiourea derivatives could become potential TMV inhibitors.</div>
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Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives.

Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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